Featured Portfolio Companies

LynxBio is developing a platform technology, MicroC3, to assist doctors in rapidly identifying the most effective treatment options in cancer patients by characterizing patient-specific cancer behavior and evolution. MicroC3 creates a miniaturized living model of a patient’s cancer to assess cancer behaviors and responses to specific drugs through imaging-based analytics. LynxBio’s initial focus is on blood cancers (myeloma and leukemia) as existing technologies such as genetic testing are unavailable or inadequate. With a turnaround time of 3-5 days, LynxBio utilizes their SystemOn-Chip biopsy technology to quickly determine the most effective treatment options for an individual patient before therapy begins, and may continue to be utilized throughout the evolution of the disease to reduce the use of ineffective treatments.

Healionics is a clinical-stage company that addresses the need for improved means of vascular dialysis access for patients with kidney
failure. Their STARgraft artificial blood vessel is designed to eliminate common issues arising from other synthetic vascular grafts – occlusion of the vessel due to scar tissue and infection due to bacterial preference for conventional ePFTE material. STAR biomaterial resists infection and scarring, reducing dangerous bacterial infections and preventing degradation/impairment of the vessel and subsequent replacement. In addition to improving vascular access for hemodialysis patients, STAR biomaterial has applications in other biomedical implants and prosthetics, including coronary artery bypass and vascular access ports for needle-free dialysis.

Paradigm brings cutting-edge diagnostics and biomarker driven clinical trials to benefit cancer patients with their Paradigm Cancer Diagnostic (PCDx) genetic testing. Through Next-Gen Sequencing, and other biomarker analysis, PCDx is able to provide fast, accurate, and actionable information about the genomic and proteomic landscape of a patient’s cancer as well as recommending potential therapies based on the specific characterization of the patient’s tumor, personalizing each patient’s course of treatment. PCDx is able to provide test results in as few as 5 days, able to diagnose using lower-quality biopsy samples, and covers biomarkers associated with a wider range of therapies than competing diagnostics.

GoSite offers small businesses an all-in-one SaaS solution to manage their online presence and customer engagement, through a hub-based web interface and mobile app featuring:

• Digital placement on all major platforms (Yelp, Google/Apple Maps, Alexa) with SEO, Google management, syncing content.
• Customer messaging through text, website chat, Facebook.
• Review management, with automated review/feedback requests.
• Booking with appointment confirmations, reminders, and automatic scheduling through an embeddable template.
• Drag-and-drop website builder with automatic mobile formatting.
• CRM Contact hub with 1-click messaging, grouping, profiling.
• Payment processing – accept credit card payments on website or in person, through mobile apps and SMS, at point of sale or
during booking.

KettleSpace transforms hospitality assets (bars, restaurants, hotels) into a network of on-demand workspaces. A turnkey digital platform allows users to access the network of available spaces for meeting and working while allowing venues to upload, manage, and monetize their properties in the network. By utilizing existing infrastructure during downtime, KettleSpace is able to quickly and flexibly offer co-working and meeting spaces, in high-value hightraffic areas. Users are able to go to locations closer to their home or office rather than a central hub, venues are able to monetize offpeak hours on an as-available basis, and KettleSpace is able to quickly expand and open new locations in expensive areas without significant real estate leasing or construction costs.

Elysium Therapeutics developed a new class of abuse-deterrent opioids that protect patients from oral misuse, drug abuse, and fatal overdose, with two platform technologies that designed to enhance the ability of patients and physicians to employ effective opioidbased pain management and prescription drug abuse. One formulation stops oral abuse and overdose by making exposure to the active agent nonlinear, eliminating the ‘high’ that traditional opioids provide when abused with high doses – stopping abuse or even preventing the initial addiction. Their second technology is an opioid antagonist that can deactivate opioids in pain medicine once the prescribed usage period has passed, rendering them ineffective for trafficking.

Elemeno Health provides a cloud-based support for front-line health care teams – a context-driven micro learning platform that transforms institutional best-practices into bite-sized chunks to advance quality and patient safety at the point of care. Their ‘just-intime’ training allows medical professionals to access interactive guidelines, smart checklists, concise how-to videos, and advances adoption and adherence of best practices through recognition and gamification. Complicated practices and guidance around issues such as infection, cancer screenings, and opioid safety are brokendown and simplified into targeted training, and team members remain motivated to learn and implement them through competition with one another to improve compliance.

DTx Pharma is opening up new opportunities for RNA therapeutics by developing technology to address a critical barrier to further adoption of nucleic-acid based drugs (oligonucleotides) as a therapeutic class – delivery. Finding safe and effective ways to get RNA outside the liver would allow access to undruggable targets in autoimmune disease, neurodegenerative disease, cancer, glaucoma, or metabolic disease – as well as providing specific advantages the RNA delivery mechanism possesses with respect to duration and efficacy that differentiates it from small molecules, antibodies and other oligo mechanisms. DTx has developed lipidation technology that enables delivery of oligos in vivo at therapeutically relevant doses, allowing competition with small molecules and biologics as well as targeting areas they are unable to modulate.

Brius has developed a revolutionary orthodontic method that can be used in place of braces or aligners. Using computer vision, new materials, and a new method of moving teeth, their orthodontic appliance works invisibly due to placement behind the teeth. Traditional orthodontics move individual teeth, using surrounding teeth as anchoring; Brius moves each tooth individually and simultaneously, cutting treatment time in half and requiring only a quarter of the visits to an orthodontist that traditional braces require – with less pain and discomfort. Avoiding the aesthetic issues with braces, the strict scheduling of aligners, and even providing a more hygenic experience as they are easily cleaned and allow flossing, Brius are also able to compete at the same price point as braces or orthodontically supervised aligners.

Actuate Therapeutics develops small molecule therapeutics for the treatment of cancer and fibrotic diseases by targeting a GSK3B enzyme inhibitor. Their lead drug candidate is a first-in-class small molecule for the treatment of high impact carcinomas including glioblastoma, ovarian, breast, lung, brain, and pancreactic cancers. Results from studies have included complete and durable regressions of disease without recurrences and significant increases in overall survival, and has shown significant anti-tumor activity in models of difficult to treat cancers. Actuate is also developing compounds for the treatment of inflammation leading to fibrosis and neurodegeneration under the same principle of GSK3B regulation.

Atlazo combines an innovative and energy-efficient AI, a flexible bio-sensing interface, and low-power wireless capability in a novel System-on-Chip for the healthcare wearables and Internet of Things markets. Utilizing edge computing on a device rather than AI analysis in the cloud, Atlazo is able to offer a revolutionary proprietary signal processing capacity that will enable innovative new applications in the wearables and IOT markets that were not possible with preexisting technologies. Current devices use imagebased AI which must be uploaded to the cloud for machine learning and analysis/detection; Atlazo is able to perform AI analysis on the chip and upload only the results to the cloud – protecting your data, minimizing signal corruption or loss, and massively reducing the power needed to send information, enabling miniaturization of devices and longer battery life.

Lennd is event and venue management platform that simplifies and centralizes event operations. Event management teams can use Lennd as their core database/platform to collect, store, manage, and integrate the most critical operational information – vendors, exhibitors, sponsors, artists, inventory, documents, contracts, media, press, and volunteer credentials – Lennd will manage every relevant piece of data for an event. Working with some of the most notable event organizations around the world, including Outside Lands Music Festival, NFL, Newport Folk and Jazz Festival, Farmer’s Insurance Open, Life Is Beautiful Music and Arts Festival, and more, Lennd wants to do for events what Salesforce did for enterprise.

Grolltex – short for Graphene Rolling Technologies – creates products based in single-layer, chemical vapor deposition (CVD) generated graphene. Through advanced transfer and processing methods, Grolltex produces single-layer graphene at a cost structure better than any on the market. Their methodology enables them to reuse and optimize the copper substrate graphene is transferred from, which is ordinarily rendered unusable by the transfer process, allowing them to produce high quality, highthroughput, cost-effective, and environmentally sustainable graphene products. Grolltex is also a provider of CVD Hexagonal Boron Nitride (hBn).

Spiral Genetics develops software to compare large populations of whole human genomes at scale, working with governments, pharmaceutical companies and academic research institutions to compare and mine whole genome datasets for novel discoveries that will lead to new diagnostics and treatments. Their BioGraph Engine facilitates and accelerates the next level of genetic analysis from days to hours – combining datasets across populations to make new discoveries – by taking a fundamentally new approach to raw sequencing data and converting it to a highly efficient graph structure, eliminating trade-offs between storage footprint, computing costs, and quality of analysis. They also offer Spiral Encrypted Compression, a new method of efficient, lossless, and encrypted data archival of large genetic datasets.

Ceresti Health aims to improve the quality and reduce cost outcomes for patients with multiple chronic conditions who are also suffering from Alzheimer’s Disease and other dementias. Managing a dementia patient’s other diseases and conditions is a challenge as patients are often unable to communicate their symptoms, compounded by the fact that most caregivers are unpaid and untrained family members without nursing experience. Ceresti helps manage the difficulties presented by these patients through a digitally-aided family caregiver empowerment program, personalized to the patient and family caregiver’s needs, providing care coaching, education, and a suite of digital tools for accessing support and resources, engaging the patient, monitoring and tracking their condition, and communicating with Ceresti’s coaches.

Habitu8 is a cybersecurity enterprise software provider that protects companies from their own employees. The large majority of data breaches are the result of an employee’s lack of security awareness, leading to basic and avoidable mistakes becoming security disasters. Habitu8 helps companies build security awareness programs, employee training videos, and institute best practices for data security and cyber hygiene in their organization. Replacing bad habits with good ones, Habitu8 provides engaging video training based on industry expertise and neuroscientific principles to redefine what effective security awareness program looks like and ensure greater employee compliance.

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